not using an installer

Many experienced Python developers prefer to handle installing packages on their own. If you don't like pip you can get the latest tarballs from http://pypi.python.org/pypi/tiddlyweb and http://pypi.python.org/pypi/tiddlywebwiki and process setup.py in whatever way you deem reasonable.

install or run from source

TiddlyWeb can be run directly from a checkout of its code from the source repository:

git clone git://github.com/tiddlyweb/tiddlyweb.git
cd tiddlyweb

(or a clone of your own fork, if you work that way)

Read the README file you will find there to see the other modules you need to install.